BICYCLIC DERIVATIVES AS GABAA A5 RECEPTOR MODULATORS

The present invention provides compounds of formula (I) and/or salt thereof and/or geometric isomer thereof and/or stereoisomer thereof and/or enantiomer thereof and/or racemate thereof and/or diastereomer thereof and/or biologically active metabolite thereof and/or prodrug thereof and/or solvate thereof and/or hydrate thereof and/or polymorph thereof having affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 and act as GABAA alfa5 negative allosteric modulators, thereby useful in the treatment or prevention of diseases related to the GABAA alfa5 receptor, process for the preparation thereof, pharmaceutical compositions comprising them alone or in combination with one or more other active ingredients and their use as medicaments. 本发明提供式(I)的化合物和/或其盐和/或其几何异构体和/或其立体异构体和/或其对映异构体和/或其消旋体和/或其非对映异构体和/或其生物活性代谢物和/或其前药和/或其溶剂合物和/或其水合物和/或其多晶型，其对γ-氨基丁酸A受体亚单元α5具有亲和性及选择性且充当为GABAAα5负向别构调节剂，由此有用于治疗或预防与GABAAα5受体相关的疾病，提供其制备方法、包含它们单独或与一种或多种其他活性成分组合的药物组合物及它们作为药物的用途。