Preparation method of cyclopropylamine intermediate cyclopropanecarboxylic acid methyl ester

The invention relates to a preparation method of a cyclopropylamine intermediate methyl cyclopropanecarboxylate, and solves the technical problems that an existing preparation method is unreasonable, high in requirements on reaction equipment, complicated to operate, low in yield and unsuitable for industrial production. With methyl acetate and 1,2-dihaloethane as raw materials, and under the action of potassium carbonate and a phase transfer catalyst, alkylation reaction is carried out to obtain methyl cyclopropanecarboxylate. The method can be widely applied to the technical field of synthesis of medical intermediates. 本发明涉及一种环丙胺中间体环丙甲酸甲酯的制备方法，其解决了现有制备方法不合理，存在反应设备要求高、操作复杂、收率低、不适合工业化生产的技术问题，本发明是以乙酸甲酯和1，2-二卤代乙烷为原料，在碳酸钾和相转移催化剂的作用下，经过烷基化反应得到环丙甲酸甲酯。本发明可广泛应用于医药中间体合成技术领域。