Application of marker in preparation of diagnostic kit or therapeutic drug for rheumatoid arthritis

The invention relates to the field of disease diagnosis technology and preparation of therapeutic drugs, in particular to application of a marker in preparation of a diagnostic kit or therapeutic drug for rheumatoid arthritis. In the application, the marker is a synovial cell supernate exosome lncRNA SNHG5 or a truncated sequence thereof; and the sequence of the lncRNA SNHG5 is as shown in SEQ ID NO: 1. The research finds that the expression of the synovial cell exosome lncRNA SNHG5 in rheumatoid arthritis patients is obviously increased compared with that in osteoarthritis patients, and by means of the exosome lncRNA SNHG5, a therapeutic target and an important basis are provided for not only early-stage rapid detection of the rheumatoid arthritis, but also clinical application such as gene therapy and drug therapy. 本发明涉及疾病诊断技术和制备治疗药物领域，特别涉及一种标志物在制备类风湿关节炎诊断试剂盒中或治疗类风湿关节炎药物中的应用。该应用中标志物为滑膜细胞上清液外泌体lncRNA SNHG5或其截短序列；lncRNA SNHG5的序列如SEQ ID NO：1所示。本发明研究发现滑膜细胞外泌体lncRNA SNHG5在类风湿关节炎患者中较骨关节炎患者表达明显增高，利用外泌体lncRNA SNHG5