METHOD TO CORRECT ION SOURCE INEFFICIENCIES MAKES SAMPLE-TO-SAMPLE NORMALIZATION POSSIBLE

In mass spectrometry significant error is introduced during sample preparation (sample-to-sample error), during ion generation (ion suppression), and during ion transmission (ion transmission losses). We demonstrate the ability to correct for ion suppression and ion transmission losses, and that once corrected for ion losses, a sample-to-sample normalization of the analytical sample to the internal standard is possible. By normalizing to a standard sample the analytical sample becomes completely comparable to any similarly treated sample. 在质谱法中，显著误差在样品制备期间(样品间误差)、在离子产生期间(离子抑制)和在离子传输期间(离子传输损耗)引入。我们证明了校正离子抑制和离子传输损耗的能力，并且一旦校正了离子损耗，则分析样品的样品间归一化到内标是可能的。通过归一化至标准样品，分析样品变得与任何类似处理的样品完全可比。