Preparation method of sucralose, crude product solution and sucralose
The invention provides a preparation method of sucralose and a crude product solution thereof, and the preparation method comprises the following steps: dissolving sucralose-6-ethyl ester in methanol to form a sucralose-6-ethyl ester reaction solution; adding tert-butylamine into the sucralose-6-eth...
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| creator | ZHOU WANQUAN XIA JIAXIN XU CHUANJIU ZHAO JINGANG |
| description | The invention provides a preparation method of sucralose and a crude product solution thereof, and the preparation method comprises the following steps: dissolving sucralose-6-ethyl ester in methanol to form a sucralose-6-ethyl ester reaction solution; adding tert-butylamine into the sucralose-6-ethyl ester reaction solution as a catalyst, and reacting under preset conditions to enable sucralose-6-ethyl ester to be subjected to deacylation reaction to form a sucralose mixed solution; and distilling the sucralose mixed solution to obtain a sucralose crude product solution. The method has the beneficial effects that the volatile tert-butylamine is adopted as the catalyst, the catalyst can be removed and recycled through a simple distillation process while the sucralose-6-ethyl ester deacylation reaction is efficiently and reliably catalyzed, the process step of separating the catalyst is simplified, the material consumption and the wastewater generation amount are reduced, and the production cost is reduced. Th |
| format | Patent |
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The method has the beneficial effects that the volatile tert-butylamine is adopted as the catalyst, the catalyst can be removed and recycled through a simple distillation process while the sucralose-6-ethyl ester deacylation reaction is efficiently and reliably catalyzed, the process step of separating the catalyst is simplified, the material consumption and the wastewater generation amount are reduced, and the production cost is reduced. Th</description><language>chi ; eng</language><subject>CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY ; CHEMISTRY ; DERIVATIVES THEREOF ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PERFORMING OPERATIONS ; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL ; SUGARS ; THEIR RELEVANT APPARATUS ; TRANSPORTING</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210507&DB=EPODOC&CC=CN&NR=112771060A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20210507&DB=EPODOC&CC=CN&NR=112771060A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHOU WANQUAN</creatorcontrib><creatorcontrib>XIA JIAXIN</creatorcontrib><creatorcontrib>XU CHUANJIU</creatorcontrib><creatorcontrib>ZHAO JINGANG</creatorcontrib><title>Preparation method of sucralose, crude product solution and sucralose</title><description>The invention provides a preparation method of sucralose and a crude product solution thereof, and the preparation method comprises the following steps: dissolving sucralose-6-ethyl ester in methanol to form a sucralose-6-ethyl ester reaction solution; adding tert-butylamine into the sucralose-6-ethyl ester reaction solution as a catalyst, and reacting under preset conditions to enable sucralose-6-ethyl ester to be subjected to deacylation reaction to form a sucralose mixed solution; and distilling the sucralose mixed solution to obtain a sucralose crude product solution. The method has the beneficial effects that the volatile tert-butylamine is adopted as the catalyst, the catalyst can be removed and recycled through a simple distillation process while the sucralose-6-ethyl ester deacylation reaction is efficiently and reliably catalyzed, the process step of separating the catalyst is simplified, the material consumption and the wastewater generation amount are reduced, and the production cost is reduced. 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The method has the beneficial effects that the volatile tert-butylamine is adopted as the catalyst, the catalyst can be removed and recycled through a simple distillation process while the sucralose-6-ethyl ester deacylation reaction is efficiently and reliably catalyzed, the process step of separating the catalyst is simplified, the material consumption and the wastewater generation amount are reduced, and the production cost is reduced. Th</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL SUGARS THEIR RELEVANT APPARATUS TRANSPORTING |
| title | Preparation method of sucralose, crude product solution and sucralose |
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