Preparation method of sucralose, crude product solution and sucralose

The invention provides a preparation method of sucralose and a crude product solution thereof, and the preparation method comprises the following steps: dissolving sucralose-6-ethyl ester in methanol to form a sucralose-6-ethyl ester reaction solution; adding tert-butylamine into the sucralose-6-eth...

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Bibliographische Detailangaben
Hauptverfasser: ZHOU WANQUAN, XIA JIAXIN, XU CHUANJIU, ZHAO JINGANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention provides a preparation method of sucralose and a crude product solution thereof, and the preparation method comprises the following steps: dissolving sucralose-6-ethyl ester in methanol to form a sucralose-6-ethyl ester reaction solution; adding tert-butylamine into the sucralose-6-ethyl ester reaction solution as a catalyst, and reacting under preset conditions to enable sucralose-6-ethyl ester to be subjected to deacylation reaction to form a sucralose mixed solution; and distilling the sucralose mixed solution to obtain a sucralose crude product solution. The method has the beneficial effects that the volatile tert-butylamine is adopted as the catalyst, the catalyst can be removed and recycled through a simple distillation process while the sucralose-6-ethyl ester deacylation reaction is efficiently and reliably catalyzed, the process step of separating the catalyst is simplified, the material consumption and the wastewater generation amount are reduced, and the production cost is reduced. Th