Engineering bacterium for producing spermidine

The invention discloses an engineering bacterium for producing spermidine, and belongs to the field of genetic engineering. According to the invention, a metabolic engineering transformation method is adopted, various product inhibition of a spermidine synthesis path is relieved, a spermidine transp...

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Bibliographische Detailangaben
Hauptverfasser: DENG HUAXIANG, BAI YAJUN, DING YANRUI, CAI YUJIE, LIANG XINXIN, HUI HONGJIE, ZHENG XIAOHUI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses an engineering bacterium for producing spermidine, and belongs to the field of genetic engineering. According to the invention, a metabolic engineering transformation method is adopted, various product inhibition of a spermidine synthesis path is relieved, a spermidine transport system is changed, the enzyme activity of a key path is enhanced, and an exogenous path is introduced, so that the escherichia coli engineering bacterium capable of producing spermidine at high yield is obtained. The engineering bacterium has good industrial application prospects. 本发明公开了一种生产亚精胺的工程菌,属于遗传工程领域。本发明采用代谢工程改造的方法,解除亚精胺合成途径的各种产物抑制、改变亚精胺转运系统、强化关键通路的酶活性、并引入外源途径,获得了一株高产亚精胺的大肠杆菌工程菌。具有良好的工业应用前景。