Preparation method of 4(3H)-quinazolinone compound

The invention discloses a preparation method of a 4(3H)-quinazolinone compound, and relates to the technical field of organic synthesis, 2,3-diketone indoline is used as a raw material, sodium hypochlorite or potassium hypochlorite is used as an oxidant, an oxidation reaction is carried out in a rea...

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Bibliographische Detailangaben
Hauptverfasser: FENG YISI, FENG HUIYI, XIE DALE, HE YONG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a preparation method of a 4(3H)-quinazolinone compound, and relates to the technical field of organic synthesis, 2,3-diketone indoline is used as a raw material, sodium hypochlorite or potassium hypochlorite is used as an oxidant, an oxidation reaction is carried out in a reaction solvent, and the 4(3H)-quinazolinone compound is prepared by a one-pot method. According to the method, 2,3-diketoindoline is used as a raw material, sodium hypochlorite or potassium hypochlorite which is easily available as the raw material is used as an oxidizing agent; the target product is prepared by a one-pot method, the reaction time is short, and the yield is high. The product is high in purity and is suitable for industrial application. 本发明公开了一种4(3H)-喹唑啉酮类化合物的制备方法,涉及有机合成技术领域,以2,3-二酮二氢吲哚作为原料,以次氯酸钠或次氯酸钾作为氧化剂,在反应溶剂中进行氧化反应,一锅法制备4(3H)-喹唑啉酮类化合物;本发明以2,3-二酮二氢吲哚作为原料,以原料易得次氯酸钠或次氯酸钾为氧化剂,一锅法制备目标产物,反应时间短,收率高。纯度高,适合工业化生产。