Application of googerotin used as antineoplastic medicine

For a kind of structure known googertin, the external test uses the cultured humanbody cancer cell (KB cell), the clone for mation determination method checks it possessing of killing and wounding actions to the KB cell, the concentration for inhibiting 50% clone formation is 3 mug/ml. The internal test uses colonic cancer 26 and sarcoma 180, the small piece of colonic cancer 26 tissue is inoculated to the axillary subdutaneous tissue of BALB/c mouse or the sarcoma 180 ascites of mouse is diluted with physiologic saline (1:3) and then inoculated to the axillary subcutaneous tissue of Kunming mouse. After 24 hr., the administration of intra-abdominal injection (ip) and gastric perfusion. (PO) are conducted, the inhibition rate for cancer is as follows: for colonic cancer (ip) 41-43%, (po) 72-86%, for sarcoma 180 (po) 80%. The results are close to that of 5-fluorouracil.