Antibody targeting CLDN18.2, and preparation method and application of antibody

The invention discloses an antibody targeting CLDN18.2, and a preparation method and application of the antibody. The antibody comprises VL and/or VH, wherein the VH comprises the following CDR sequences: a VH CDR1 amino acid sequence as shown in SEQ ID NO: 6, a VH CDR2 amino acid sequence as shown in SEQ ID NO: 7, and/or a VH CDR3 amino acid sequence as shown in SEQ ID NO: 8; and the VL comprises the following CDR sequences: a VL CDR1 amino acid sequence as shown in SEQ ID NO: 17, a VL CDR2 amino acid sequence as shown in SEQ ID NO: 18, and/or a VL CDR3 amino acid sequence as shown in SEQ ID NO: 19. Compared with the prior art, the antibody provided by the invention has obvious advantages of high binding affinity, good ADCC, CDC and growth inhibition effects, high endocytosis activity and the like. 本发明公开了靶向CLDN18.2的抗体及其制备方法和应用。所述抗体包含VL和/或VH，所述VH包含以下CDR序列：如SEQ ID NO:6所示的VH CDR1氨基酸序列；如SEQ ID NO:7所示的VH CDR2氨基酸序列；和/或如SEQ ID NO:8所示的VH CDR3氨基酸序列；所述VL包含以下的CDR序列：如SEQ ID NO:17所示的VL CDR1氨基酸序列；如SEQ ID NO:18所示的VL CDR2氨基