Method for preparing semetinib

The invention relates to a method for preparing an MEK1/2 inhibitor smeltinib, which comprises the following steps: carrying out three-step reaction on the synthetic route to synthesize the smeltinib, carrying out post-treatment on the synthetic method without column chromatography separation, and directly precipitating and drying the reaction product. By utilizing the synthesis and preparation method disclosed by the invention, the smeltinib can be rapidly and effectively prepared. 本发明涉及一种制备MEK1/2抑制剂司美替尼的方法，本发明的合成路线经三步反应合成得到司美替尼，其合成方法的后处理均无需柱层析分离，反应产物直接析出干燥即可。利用本发明所述的合成制备方法，其能够快速、有效地制备获得司美替尼。