Synthesis method of key raw material 2-chloro-6-methylaniline of dasatinib

The invention discloses a synthetic method of a key raw material 2-chloro-6-methylaniline of dasatinib. The method comprises the following steps: firstly, protecting a 1-site amino group of 2-nitro-6-methylaniline, then reducing a 2-site nitro group of 2-nitro-6-methylaniline into an amino group, then carrying out diazotization reaction, carrying out chlorine substitution on the 2-site amino group by using cuprous chloride, and finally, carrying out acidolysis to remove a 1-site amino protecting group to obtain 2-chlorine-6-methylaniline. The method has the advantages of cheap and easily available raw materials, easily controllable reaction, simple operation steps, simple post-treatment, recyclable solvents, small pollution, and suitableness for large-scale production of generative enterprises. 本发明公开了一种达沙替尼关键原料2-氯-6-甲基苯胺的合成方法。该方法首先对2-硝基-6-甲基苯胺的1位氨基进行保护，再将其2位硝基还原为氨基，然后通过重氮化反应并以氯化亚铜进行氯取代2位氨基，最后经酸解脱去1位的氨基保护基得到2-氯-6-甲基苯胺。该方法的原料便宜易得，反应易于控制，操作步骤简单，后处理简单，所用溶剂均可回收套用，污染小，较适合生成型企业的放大生产。