XYLR MUTANT FOR IMPROVED XYLOSE UTILIZATION OR IMPROVED CO-UTILIZATION OF GLUCOSE AND XYLOSE

The disclosure relates to mutant gene(s) that confer upon microorganisms that express them an improved capacity to utilize xylose and improved capacity to co-utilize glucose and xylose thereby resulting in improved growth of the microorganism. Further encompassed are methods of producing fatty acids...

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Hauptverfasser:	VENKITESWARAN SANKARANARAYANAN, WONG LELAND KEN, PAYNE STEPHEN THOMAS, DA COSTA BERNARDO MOURA TORRES, CALLIHAN ISOLDE, FRYKMAN SCOTT ALLEN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The disclosure relates to mutant gene(s) that confer upon microorganisms that express them an improved capacity to utilize xylose and improved capacity to co-utilize glucose and xylose thereby resulting in improved growth of the microorganism. Further encompassed are methods of producing fatty acids and fatty acid derivatives from cellulosic biomass, xylose, and/or a glucose/xylose mix by employing the host cells expressing the engineered XylR variants and compositions of biologically produced fatty acids and fatty acid derivatives. 本公开涉及一种或多种突变基因，所述突变基因赋予表达它们的微生物改善的利用木糖的能力和改善的共利用葡萄糖和木糖的能力，从而导致所述微生物的改善的生长。进一步包括通过使用表达经工程改造的XylR变体的宿主细胞从纤维素生物质、木糖和/或葡萄糖/木糖混合物产生脂肪酸和脂肪酸衍生物的方法，以及生物产生的脂肪酸和脂肪酸衍生物的组合物。