Application of berberrubine to preparation of anti-insomnia medicine

The invention belongs to the technical field of medicines, and particularly relates to an application of berberrubine to preparation of an anti-insomnia medicine. Pre-clinical animal research shows that the berberrubine or a solvate thereof or a pharmaceutical salt or hydrate or prodrug thereof has the effects of increasing the content of 5-HT in hippocampus and hypothalamus, increasing the content of MT in serum hormone, increasing the content of GABA in the hippocampus, reducing the content of ACTH and CRH in serum hormone and reducing the content of GLU in the hippocampus, and has a definite anti-insomnia effect. Further development and utilization of the berberrubine are facilitated. 本发明属于医药技术领域，具体涉及小檗红碱用于制备抗失眠药物的用途。临床前动物研究显示小檗红碱或其溶剂化物或其药用盐或水合物或前药具有提高海马和下丘脑中5-HT含量，提高血清激素中MT含量，提高海马中GABA含量，降低血清激素中ACTH和CRH含量，降低海马中GLU含量的作用，有明确的抗失眠作用，有助于小檗红碱的进一步开发利用。