Photoactivated novel organic small-molecular matrixes and preparation method thereof, and application of photoactivated novel organic small-molecular matrixes in MALDI mass spectrometric detection

The invention provides photoactivated novel organic small-molecular matrixes and a preparation method thereof, and application of the photoactivated novel organic small-molecular matrixes in MALDI mass spectrometric detection. According to the invention, compounds with structures shown in a formula I, a formula II and a formula III are used as matrixes of MALDI mass spectrometry. In a positive ion detection mode of MALDI mass spectrometry, organic compounds of the series of matrixes can be activated into cationic free radicals that react with halogen ions to form bridge bonds with more stable energy; the above process improves the compounding efficiency of molecules of an analyte to be detected and sodium ions and facilitates substance separation by flying in an electric field; the matrixes have excellent performance in detecting mass spectrum signals of various small molecules, and is low in background noise and high in signal-to-noise ratio. 本发明提供了光激活新型有机小分子基质、制备方法及其在MALDI质谱检测中的应用，本发明将具有式Ⅰ、式Ⅱ和式Ⅲ结构的化合物作为MALD