Circular RNA vector and application thereof in vaccines

The invention discloses a circular RNA vector and application thereof in vaccines, the vector structurally comprises a circular RNA translation starting area, a protein positioning guide area, a protein translation RNA fragment insertion point and a structure enhancing area, the circular RNA vector has a strong translation function, can translate protein of a protein translation RNA fragment into protein and transfer the protein to a proper area, and the protein translation RNA fragment insertion point is inserted into the protein translation RNA fragment insertion point. Compared with an mRNA vaccine, the vector capable of acting on the RNA vaccine has a plurality of advantages and can be used as a vaccine for prevention or treatment. 本发明公开了一种环状RNA载体及其在疫苗中的应用，该载体中的结构为包括环状RNA翻译启动区，蛋白定位引导区，蛋白翻译RNA片段插入点，结构增强区，该环状RNA载体具有较强的翻译功能，可以将蛋白翻译RNA片段的蛋白质翻译成蛋白并转让到适当区域，可以作用RNA疫苗的载体，比mRNA疫苗具有若干优点，可用于为预防或治疗的疫苗。