Modified PPP1R12A circular RNA vector and application thereof

The invention discloses a modified PPP1R12A circular RNA vector and application thereof, and is characterized in that the modified PPP1R12A circular RNA vector has translation starting capability, for example, a section of RNA with translation potential is added in the middle, the PPP1R12A circular...

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Bibliographische Detailangaben
Hauptverfasser:	ZHOU QIAN, YIN JINYAO, SUN MINGJUN, MAO YIZHU, HE YUEFENG, TAN JINGWEN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a modified PPP1R12A circular RNA vector and application thereof, and is characterized in that the modified PPP1R12A circular RNA vector has translation starting capability, for example, a section of RNA with translation potential is added in the middle, the PPP1R12A circular RNA vector can stably express the protein, the protein antibody can be generated when the protein enters an immune animal body, and the PPP1R12A circular RNA can be used as a vaccine vector, and can be used for prevention or treatment. 本发明公开了一种改造的PPP1R12A环状RNA载体及其应用，其特征是：改造的PPP1R12A环状RNA载体具有启动翻译的能力，如在中间加入一段具有翻译潜力的RNA，PPP1R12A环状RNA载体可稳定的表达该蛋白，进入到免疫动物体内可以产生该蛋白抗体，PPP1R12A环状RNA可以作为疫苗的载体，可用于为预防或治疗的疫苗。