ANTI-ABETA ANTIBODIES AND USES THEREOF

An isolated antibody structurally comprises a light chain CDR1, a light chain CDR2, a heavy chain CDR1, a heavy chain CDR2 and a heavy chain CDR3, and the antibody has specific binding capacity to A beta 142 or N-terminal modified A beta 142. The antibody can be used for treating AD and early detecting the content of brain A beta. N-terminal modified pyroglutamic acid A [beta] (pE-A[beta] 3-42) isvery easy to aggregate and may be very important for A [beta] plaque formation. 一种分离的抗体，其结构包含：轻链CDR1，轻链CDR2，重链CDR1，重链CDR2，以及重链CDR3，所述抗体对Aβ1-42或N端修饰型Aβ1-42都具有特异性结合能力。该抗体可用于治疗AD和早期检测脑Aβ含量。N端修饰的焦麸氨酸Aβ(pE-Aβ3-42)非常易于聚集，并且对Aβ斑块形成可能很重要。