Improved method for preparing (Z, E)-12-tetradecene-1-alcohol acetate
The invention provides an improved method for preparing (Z, E)-12-tetradecene 1-alcohol acetate, which innovatively introduces a three-solvent system into a solvent system in wittig reaction, increases the solubility of the reagent in the reaction system, lowers the overall freezing point of the sol...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention provides an improved method for preparing (Z, E)-12-tetradecene 1-alcohol acetate, which innovatively introduces a three-solvent system into a solvent system in wittig reaction, increases the solubility of the reagent in the reaction system, lowers the overall freezing point of the solvent, avoids the agglomeration phenomenon at lower temperature in the reaction process under dual actions, and unsmooth reaction stirring and generation of a large number of impurities are avoided, so that the post-treatment difficulty is increased; glacial acetic acid is used for terminating the reaction and replacing previous water-containing dilute acid, condensation of residual aldehydes in the raw materials is controlled, generation of a large number of impurities is avoided, and once a condensation product generates p-triphenylphosphine oxide and a main product enol which are high in solubility and cannot be separated, the aftertreatment difficulty can be greatly enhanced, and the product extraction loss is l |
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