Preparation method of cefotetan disodium bulk drug

The invention discloses a preparation method of a cefotetan disodium bulk drug, which comprises the following steps: reacting 7-MAC (II) with 2, 2-dimercaptoacetic acid to prepare a compound III, reacting the compound III with 3-amino-2-formyl -3-oxo sodium propionate to prepare a compound IV, and carrying out deprotection and salification to obtain cefotetan disodium (I). The preparation method is simple and convenient, the reaction conditions are mild, and the obtained cefotetan disodium bulk drug is high in purity and suitable for industrial production. 本发明公开了一种头孢替坦二钠原料药的制备方法，本发明将7-MAC(Ⅱ)与2,2-二巯基乙酸反应制备化合物III，化合物III与3-氨基-2-甲酰基-3-氧代丙酸钠进行反应制备化合物IV，再经过脱保护、成盐制得头孢替坦二钠(I)。本发明制备方法简捷且反应条件温和，所得的头孢替坦二钠原料药纯度高，适合工业化生产需要。