LPAR1 for coordinating ciliogenesis and neurogenesis in cortex development process

The invention discloses LPAR1 for coordinating ciliogenesis and neurogenesis in a cortex development process. The invention provides an application of LPAR1 protein or a related biological material thereof in any one of the following aspects of coordinating ciliogenesis and/or neurogenesis in the cortex development process; and preparing a product for coordinating ciliogenesis and/or neurogenesisin the cortex development process, wherein the related biological material is a nucleic acid molecule capable of expressing the LPAR1 protein or an expression cassette, a recombinant vector, a recombinant bacterium or a transgenic cell line containing the nucleic acid molecule. Research finds that LPAR1 is crucial to normal occurrence of cilia on mouse RG cells, VZ/SVZ generation and new cortex formation. The LPAR1 may modulate neurogenesis by precisely regulating the dynamic balance of cilium assembly and disassembly. 本发明公开了LPAR1协调皮层发育过程中的纤毛发生和神经发生。本发明提供了LPAR1蛋白或其相关生物材料在如下任一中的应用：协调皮层发育过程中的纤毛发生和/或神经发生；制备用于协调皮层发育过程中的纤毛