INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION

Compounds of formula (I): R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain. 式(I)的化合物：其中、R1、R2、R3、R4a、R4b和R5如本文所述，或其立体异构体、对映体或互变异构体或它们的混合物，或其药学上可接受的盐或溶剂化物，以及其它化合物。这些化合物可用于治疗炎症和/或疼痛。还公开了包含本发明的化合物的组合物以及使用所述化合物治疗炎症和/或疼痛的方法。