OLIGONUCLEOTIDES FOR MODULATING RTEL1 EXPRESSION

The present invention relates to a RTEL1 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of RTEL1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to antisense oligonucleotide...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	WALLIER ANGELINA, KAM-THONG TONY, TROPBERGER PHILIPP, BERRERA MARCO, KAMMLER SUSANNE, LEONARD BRIAN, FELBER JOSEPHINE, HOFLACK JEANRISTOPHE, TRIYATNI MIRIAM, ZHANG JITAO DAVID, PEDERSEN LYKKE, TURLEY DANIEL JEREMY
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention relates to a RTEL1 inhibitor for use in treatment of an HBV infection, in particular a chronic HBV infection. The invention in particular relates to the use of RTEL1 inhibitors for destabilizing cccDNA, such as HBV cccDNA. The invention also relates to antisense oligonucleotides which are complementary to RTEL1 and capable of reducing a RTEL1 mRNA. Also comprised in the present invention is a pharmaceutical composition and its use in the treatment and/or prevention of a HBV infection. 本发明涉及一种RTEL1抑制剂，其用于在HBV感染，特别是慢性HBV感染的治疗中的用途。本发明特别地涉及用RTEL1抑制剂使cccDNA，例如HBV cccDNA不稳定。本发明还涉及与RTEL1互补并且能够减少RTEL1mRNA的反义寡核苷酸。本发明还包括一种药物组合物及其在HBV感染的治疗和/或预防中的用途。