BISPECIFIC T CELL ADAPTER PROTEIN AND USES THEREOF

The present disclosure provides a novel fusion protein to overcome the current difficulties related to application of monoclonal antibodies in disease treatment and in other fields, particularly thoserequiring ADCC, e.g. for depletion of tumor cells, virally-infected cells, or immune-modulating cells, etc. One example of the fusion protein preferably comprising an extracellular domain of a high-affinity variant of human CD 16 A fused to an anti-CD3 antibody or its antigen-binding fragment thereof that specifically binds to an epitope on human CD3 or a fragment thereof. 本揭示提供了一种新颖的融合蛋白，以克服现今单株抗体在疾病治疗及其他领域应用中相关的困难，特别是在需要ADCC的领域中，例如去除肿瘤细胞、经病毒感染的细胞或免疫调节细胞等。融合蛋白的一个优选实例包含了人类CD16A的高亲和力变异体的胞外结构域与特异性结合至人类CD3上的抗原决定位或其片段的抗CD3抗体或其抗原结合片段的融合。