Method for replacement fluorination reaction of aryl halide
The invention relates to a method for replacement fluorination of an aryl halide, and belongs to the field of preparation of fine chemical intermediates. The method comprises the following steps: mixing the aryl halide, an ionic liquid, a fluorinating agent and a reaction solvent, heating to 100-180...
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Sprache: | chi ; eng |
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Zusammenfassung: | The invention relates to a method for replacement fluorination of an aryl halide, and belongs to the field of preparation of fine chemical intermediates. The method comprises the following steps: mixing the aryl halide, an ionic liquid, a fluorinating agent and a reaction solvent, heating to 100-180 DEG C, carrying out heat preservation reaction, and treating to obtain aryl halide. The method hasthe advantages of mild conditions, smooth implementation of non-strong electron withdrawing aryl halide, good reaction selectivity, high repeatability, high yield, recoverability of the ionic liquid,reduction of the generation of wastes, facilitation of the reduction of the production cost, and environmental pollution reduction.
本发明涉及一种卤代芳烃置换氟化的方法,属于精细化工中间体制备领域。该方法是将卤代芳烃、离子液体、氟化剂和反应溶剂混合,升温至100-180℃保温反应,处理后得到卤代芳烃。该方法条件温和,对于带有非强吸电子卤代芳烃也可顺利进行,反应选择性好,可重复性高,收率高,离子液体可回收利用,减少了废物的生成,有益于降低生产成本减少环境污染。 |
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