Temperature-sensitive antibacterial hemostatic hydrogel as well as preparation method and application thereof

The invention discloses a temperature-sensitive antibacterial hemostatic hydrogel as well as a preparation method and an application thereof. According to the invention, chitosan is modified by utilizing a polyhydroxy compound and a temperature-sensitive agent to prepare xerogel, the xerogel is swel...

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Bibliographische Detailangaben
Hauptverfasser: XIANG HONGPING, ZHENG LIYU, ZHENG DANXIA, WANG ZEHUANG, ZHAO JIAWEI, ZHANG LANYUE, SHI YAOHUI, LIANG XIAOXIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a temperature-sensitive antibacterial hemostatic hydrogel as well as a preparation method and an application thereof. According to the invention, chitosan is modified by utilizing a polyhydroxy compound and a temperature-sensitive agent to prepare xerogel, the xerogel is swelled in essential oil micro-emulsion to prepare the temperature-sensitive antibacterial hemostatic hydrogel, and the modified hydrogel can be firmly adhered to the surface of a tissue; the temperature-sensitive antibacterial hemostatic hydrogel can be in a solid state at the body surface temperatureafter being in contact with the body surface, has good temperature sensitivity, has a good hemostatic effect, can wet the skin to change the cuticle structure and promote the medicine to enter the body through the skin, and therefore, the temperature-sensitive antibacterial hemostatic hydrogel also has the characteristics of good biocompatibility and strong antibacterial and anti-inflammatory effects. 本发明公开了一种温敏抗菌止血水凝胶及其制