Application of inhibitor of parvalbumin in preparation of product for preventing and treating obesity and diseases caused by obesity

The invention relates to the field of medicine, in particular to application of parvalbumin in preparation of product for preventing and treating obesity and diseases caused by obesity. The parvalbumin inhibitor is selected from a substance capable of being specifically combined with small albumin o...

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Hauptverfasser: LIN SHAOJIAN, YUAN LING, ZHANG ANKE, LUAN BING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the field of medicine, in particular to application of parvalbumin in preparation of product for preventing and treating obesity and diseases caused by obesity. The parvalbumin inhibitor is selected from a substance capable of being specifically combined with small albumin or a substance capable of being specifically combined with a small albumin target. The parvalbumin inhibitor is selected from polypeptide, and the amino acid sequence of the polypeptide is shown as SEQ ID NO. 1. The inventor of the invention finds the function and action mechanism of the parvalbumininhibitor in obesity, inhibits the combination of the parvalbumin inhibitor and the colony stimulating factor 1 receptor by designing the synthetic polypeptide, and plays a role in reducing weight andimproving insulin tolerance, fatty liver and other symptoms caused by obesity in high-fat induced obesity mice. A new theoretical basis is laid for weight reduction and obesity-related disease treatment, and a new drug action