Method for determining content of carbomer in gel containing carbomer

The invention relates to a method for detecting the content of carbomer in gel containing carbomer, which is characterized by comprising the following steps: adding a certain amount of alkali solutionto ensure that carboxylic acid groups of carbomer in the gel exist in an ionic state, adding excessi...

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Bibliographische Detailangaben
Hauptverfasser: LIU CHENG, WANG NAN, WANG KUI, GUO JIANQIONG, LI KEJIANG, GUO PEILIN, ZHU GUOHUA
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a method for detecting the content of carbomer in gel containing carbomer, which is characterized by comprising the following steps: adding a certain amount of alkali solutionto ensure that carboxylic acid groups of carbomer in the gel exist in an ionic state, adding excessive metal salt solution to ensure that metal salt is fully combined with the carboxylic acid groupsin carbomer to generate a complex, removing the complex, and titrating the uncombined metal salt by using a coordination titration solution so as to calculate the content of carbomer in the sample. The method is suitable for detecting the content of carbomer in gel taking carbomer as a gel matrix or a main component, and is simple, accurate and high in specificity. 本发明涉及一种含有卡波姆的凝胶剂中卡波姆含量的检测方法,其特征在于,加入一定量的碱溶液,使凝胶中卡波姆的羧酸基以离子状态存在,然后加入过量的金属盐溶液,使金属盐与卡波姆中的羧酸基充分结合,生成络合物,除去络合物后,再用配位滴定液滴定未结合的金属盐,从而计算得到样品中卡波姆的含量。此方法适用于以卡波姆作为凝胶基质或主成分的凝胶剂中卡波姆含量的检测,该方法简单准确,专属性强。