Novel method for inhibiting toxic and side effects of DNA toxic chemotherapeutic drugs and application
The invention relates to a novel method for reducing toxic and side effects of chemotherapeutic drugs caused by reactive oxygen species (ROS) by supplementing (injecting or taking) 5-phosphoribose (R5P) after a patient is treated by chemotherapeutic drugs. The novel method has the advantages that af...
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| creator | ZHOU SA ZHANG YUJIE JIN LIJUN MA WENJIAN MA NING ZHANG TENGYUE LI XINYU MU JIAKANG DING CHUNYANG |
| description | The invention relates to a novel method for reducing toxic and side effects of chemotherapeutic drugs caused by reactive oxygen species (ROS) by supplementing (injecting or taking) 5-phosphoribose (R5P) after a patient is treated by chemotherapeutic drugs. The novel method has the advantages that after the chemotherapeutic drugs such as psoralen are used for inducing DNA damage, the ROS level is continuously increased, if R5P is added during cell culture, ROS production is remarkably inhibited, and the DNA repair process is basically not affected or even improved. Meanwhile, the cell volume isnot increased any more (the number of mitochondria is reduced). DNA damage induced ROS is a by-product of substance and energy metabolism through metabolic pathways such as PPP, and activation of thePPP metabolic pathways is to meet the requirement of repairing specific DNA damage. Although the psoralen is mainly used as a model in the description of the invention, R5P-based drug combination canbe universally applied to |
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The novel method has the advantages that after the chemotherapeutic drugs such as psoralen are used for inducing DNA damage, the ROS level is continuously increased, if R5P is added during cell culture, ROS production is remarkably inhibited, and the DNA repair process is basically not affected or even improved. Meanwhile, the cell volume isnot increased any more (the number of mitochondria is reduced). DNA damage induced ROS is a by-product of substance and energy metabolism through metabolic pathways such as PPP, and activation of thePPP metabolic pathways is to meet the requirement of repairing specific DNA damage. Although the psoralen is mainly used as a model in the description of the invention, R5P-based drug combination canbe universally applied to</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Novel method for inhibiting toxic and side effects of DNA toxic chemotherapeutic drugs and application |
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