PYRIMIDO[4,5-D]PYRIMIDIN-2-ONE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Disclosed are a compound selected from novel pyrimido[4,5-d]pyrimidin-2-one derivative compounds having excellent anti-proliferative activity against cancer cells, pharmaceutically acceptable salts thereof, hydrates thereof and stereoisomers thereof, a method for preparing the compound, a pharmaceutical composition for preventing, alleviating or treating cancer metastasis and proliferative diseases containing the compound as an active ingredient, and an anticancer composition against cancer cells, containing the compound as an active ingredient. The compounds of this invention exhibit most excellent selective inhibitory activity against LCK and anti-proliferative activity against cancer cells, thus being useful for inhibiting cancer cells, and for preventing or treating cancer metastasis and proliferative diseases. 公开了一种化合物，所述化合物选自对癌细胞具有优异的抗增殖活性的新型嘧啶并[4,5-d]嘧啶-2-酮衍生化合物，其药学上可接受的盐，其水合物及其立体异构体，制备所述化合物的方法，用于预防、减轻或治疗癌症转移和增生性疾病的包括所述化合物作为活性成分的药用组合物，和含有所述化合物作为活性成分的针对癌细胞的抗癌组合物。本发明的所述化合物表现出最优异的对LCK的选择性抑制活性和对癌细胞的抗增殖活性，因