Method for synthesizing fluorine-containing quinolinone compound by electro-catalyzing indole by using electrochemical micro-channel reaction device

The invention discloses a method for synthesizing a fluorine-containing quinolinone compound by electro-catalyzing indole by using an electrochemical micro-channel reaction device, which is characterized by comprising the following steps of respectively and simultaneously pumping a first solution co...

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Hauptverfasser: YUAN XIN, GUO KAI, ZHUANG KAIQIANG, QIN LONGZHOU, QIU JIANGKAI, DUAN XIU, SUN QI, CUI YUSHENG, CHEN LIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a method for synthesizing a fluorine-containing quinolinone compound by electro-catalyzing indole by using an electrochemical micro-channel reaction device, which is characterized by comprising the following steps of respectively and simultaneously pumping a first solution containing an N-substituted 2-aryl indole compound shown as a formula I with a second solution containing a fluorine source and an electrolyte, reacting to obtain a reaction solution containing the fluorine-containing quinolinone compound as shown in the formula II. The micro-channel reaction device is used for preparing the fluorine-containing quinolinone compound, the reaction rate can be effectively controlled, the reaction time is shortened, continuous production is achieved, high diastereoselectivity is achieved, generation of by-products is reduced, the maximum yield can reach 98.7%, the refining process is simpler, and the product quality is improved; basically no amplification effect exists, and industrial am