Synthesis method of 2-chloro-5-chloromethylthiazole

The invention is applicable to the field of chemical synthesis, and provides a synthetic method of 2-chloro-5-chloromethylthiazole, which comprises the following steps: mixing 1-isothiocyanate-2-chloro-2-propylene and hydrochloric acid in water and/or an organic solvent to obtain a mixed solution; a...

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Hauptverfasser: CHEN DAPIN, WANG TIANJUN, LIU LIANG, YANG HUAPING, HUANG XIRU, XU ZHONGQIAN, YIN RENLI, YANG JINLIANG
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention is applicable to the field of chemical synthesis, and provides a synthetic method of 2-chloro-5-chloromethylthiazole, which comprises the following steps: mixing 1-isothiocyanate-2-chloro-2-propylene and hydrochloric acid in water and/or an organic solvent to obtain a mixed solution; adding an oxidizing agent into the mixed solution for reaction to obtain a reaction solution; performing standing and layering the reaction solution to obtain an organic layer; and cleaning the organic layer, and then carrying out reduced pressure distillation to obtain the 2-chloro-5chloro-methylthiazole. The synthesis method provided by the invention simplifies the reaction steps, the acidity of the reacted wastewater is very weak, the wastewater only needs to be slightly alkali-adjusted, the salt content is low, the treatment is easy, meanwhile, hydrochloric acid is also a relatively rich raw material in the market, is easily available and is not suitable for highly toxic chlorine in the reaction process, and the