METHODS FOR FINGERPRINTING OF BIOLOGICAL SAMPLES

The present disclosure provides methods for fingerprinting of biological samples of a subject. In an aspect, the present disclosure provides a method for identifying a sample mismatch, comprising: obtaining a first biological sample comprising a first plurality of nucleic acid molecules from a subject; processing the first plurality to generate a first sample fingerprint comprising a quantitativemeasure of the first plurality at each of a plurality of genetic loci, wherein the plurality of genetic loci comprises autosomal single nucleotide polymorphisms (SNPs); obtaining a second biological sample comprising a second plurality of nucleic acid molecules from the subject; processing the second plurality to generate a second sample fingerprint comprising a quantitative measure of the secondplurality at each of the plurality of genetic loci; determining a difference between the first sample fingerprint and the second sample fingerprint; and identifying the sample mismatch when the difference satisfies a predeterm