Novel benzodiazepine compound as well as preparation method and application thereof

The invention discloses a novel benzodiazepine compound as well as a preparation method and application thereof and belongs to the field of medicinal chemistry; the short-acting benzodiazepine derivative disclosed by the invention has the characteristics of quick acting, short acting time, strong de...

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Bibliographische Detailangaben
Hauptverfasser: CHEN BIN, ZHOU JIAQI, LI QIFEI, CAI YAN, QIAN HAI, ZOU YUXING, HUANG WENLONG, SHI WEI, MO JIAXIAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a novel benzodiazepine compound as well as a preparation method and application thereof and belongs to the field of medicinal chemistry; the short-acting benzodiazepine derivative disclosed by the invention has the characteristics of quick acting, short acting time, strong depth, quick metabolism, quick awakening and the like. In anesthesia experiments on mice and rats, theshort-acting benzodiazepine derivative disclosed by the invention is equivalent to remimazolam in acting time, but the acting time and the waking time are remarkably shortened, the acting depth of part of compounds is obviously enhanced, and the short-acting benzodiazepine derivative has the characteristics of quicker acting speed, shorter acting time, higher acting strength, quicker metabolism,quicker waking speed and the like; in a long-term infusion anesthesia experiment on rats, compared with remimazolam, the short-acting benzodiazepine derivative has the advantages that the awakening time and the recovery time a