Antibacterial peptide and application thereof

The invention provides an antibacterial peptide and an application thereof. The antibacterial peptide is derivative peptides GHaR, GHa4R and GHa11R of a Temporin-GHa (GHa), and Belongs to the field ofapplication of peptide antibiotics. Antibacterial peptide GHa is directionally modified to obtain the derivative peptides GHaR, GHa4R and GHa11R. The GHaR, the GHa4R and the GHa11R provided have stronger and faster anti-MRSA activity, and the GHa11R is likely to become a new penetrating peptide. GHaR and GHa11R have high-efficiency anti-MRSA biofilm activity, do not easily generate drug resistance, and have low cytotoxicity and high cell selectivity, so that the GHaR and the GHa11R become novel antibacterial drug candidates with great prospects in treating MRSA infection. 本发明提供了一种抗菌肽及其应用，是海南沼蛙抗菌肽Temporin-GHa(GHa)的衍生肽GHaR、GHa4R和GHa11R；属于肽类抗生素的应用领域，通过对抗菌肽GHa进行定向改造，得到衍生肽GHaR、GHa4R和GHa11R；本发明的GHaR、GHa4R和GHa11R具有更强、更快的抗MRSA活性，GHa11R有可能成为新的穿透肽；GHaR和GHa11R高效抗MRSA生物被膜活性、不易产生耐药、低细胞毒性和高细胞选择性使其成为治疗MRSA感染有巨大前景的新型抗菌药候选物。