Capture probe set for hepatitis B virus gene detection

The invention discloses a capture probe et for hepatitis B virus gene detection. The probe set comprises probes capable of specifically capturing hepatitis B virus genes of four genotypes A, B, C andD, and the probes are DNA sequences designed according to whole genome sequences of hepatitis B virus...

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Hauptverfasser: GUO JIANCHENG, WANG XIAO, DAI LIPING, WANG PENG, FENG SHUAISHENG, ZHANG JIANYING, YE HUA, LI JITIAN, SHI JIANXIANG, TANG WENXUE, CUI CHI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a capture probe et for hepatitis B virus gene detection. The probe set comprises probes capable of specifically capturing hepatitis B virus genes of four genotypes A, B, C andD, and the probes are DNA sequences designed according to whole genome sequences of hepatitis B viruses of the four genotypes A, B, C and D. The probe set for hepatitis B virus gene detection, provided by the invention, has the advantages of being easy and convenient to operate, low in cost, good in specificity, high in sensitivity and the like, various types of mutations such as mutation and deletion can be detected at the same time, the sequencing cost can be saved through the probe set and a capture sequencing method, besides, a basis is quickly provided for determination, reasonable intervention, treatment measures and the like of a treatment scheme for a hepatitis B patient, and the development trend of precision medical treatment is met. 本发明公开一种用于乙肝病毒基因检测的捕获探针组,所述探针组包含能特异性捕获A、B、C、D四种基因型的乙肝病毒基因的探针,所述探针为根据A、B、