Method for synthesizing 2-amino-3-chloro-5-trifluoromethylpyridine

The invention discloses a method for synthesizing 2-amino-3-chloro-5-trifluoromethylpyridine, and belongs to the technical field of organic synthesis. Specifically, starting from 2-aminopyridine, three chemical reactions of bromination, chlorination and coupling are involved, and two organic solvents are used in the whole process; and after the three-step reaction, recrystallization treatment is carried out to obtain the high-purity 2-amino-3-chloro-5-trifluoromethylpyridine. The method is mild in reaction condition and easy to control, and the obtained product is high in purity; reaction rawmaterials and organic solvents are easy to obtain and low in price, and a new way is provided for large-scale production. 一种合成2-氨基-3-氯-5-三氟甲基吡啶的方法，属于有机合成技术领域。具体从2-氨基吡啶出发涉及溴化、氯化和偶联三步化学反应，整体过程使用两种有机溶剂；三步反应后，再经重结晶处理后，得到高纯度2-氨基-3-氯-5-三氟甲基吡啶。本发明反应条件温和，易于控制，且得到的产品纯度高；反应原料及有机溶剂容易获得且价格便宜，为规模化生产提供了一条新的途径。