Synthesis method of 4-bromo-3-oxo-N-phenylbutyrylamide

The invention is applicable to the field of chemical synthesis, and provides a synthesis method of 4-bromo-3-oxo-N-phenylbutyramide, which comprises the following steps: putting diketene into an organic solvent, dropwisely adding bromine at -15 to 50 DEG C to react, thereby obtaining a reaction solution, adding alkali and aniline into the reaction solution to carry out heat preservation reaction,and filtering to obtain the 4bromo-3oxo-Nphenyl butyramide. According to the invention, diketene is used for reacting with bromine, then diketene is condensed with aniline to generate 4-bromo-3oxo-N-phenylbutyramide, the reaction conditions are mild, and the purpose of generating high-content 4-bromo-3-oxo-N-phenylbutyramide by a one-step method can be achieved, and the produced product can reachthe content required by subsequent production without refining, so that the method is suitable for industrial production. 本发明适用于化学合成领域，提供了一种4-溴-3-氧代-N-苯基丁酰胺的合成方法，其包括以下步骤：将双乙烯酮置于有机溶剂中，并在-15~50℃的温度下滴加溴素进行反应，得到反应液；往反应液中加入碱和苯胺进行保温