Method for separating acyclovir and sodium acetate from mother liquor

The invention discloses a method for separating acyclovir and sodium acetate from mother liquor, which comprises the following steps: S1, conducting pretreatment: concentrating the mother liquor underreduced pressure to 18-26Be at the temperature of 80 DEG C or below, conducting cooling, adding sodi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HUANG LINJUN, GUO LIANGCHEN, ZHANG BINGHONG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a method for separating acyclovir and sodium acetate from mother liquor, which comprises the following steps: S1, conducting pretreatment: concentrating the mother liquor underreduced pressure to 18-26Be at the temperature of 80 DEG C or below, conducting cooling, adding sodium hydroxide, and regulating the pH value to 9-14; S2, separating sodium acetate, namely cooling, crystallizing and spin-filtering the mother liquor treated in the step S1 for multiple times, separating out sodium acetate trihydrate under an alkaline condition, and controlling the crystallization temperature at a desalting end point to be 18-24 DEG C; and S3, separating acyclovir, namely adjusting the pH value of the filtrate desalted in the step S2 to 3-7, conducting cooling to 0-10 DEG C, conducting crystallizing, and carrying out centrifugal filtration to separate acyclovir. According to the method provided by the invention, acyclovir and sodium acetate can be separated from the mother liquor through a separatio