Supramolecular preparation of retinol and derivatives thereof and preparation method of supramolecular preparation

The invention relates to a supramolecular preparation of retinol and derivatives thereof and a preparation method of the supramolecular preparation. The supramolecular preparation is characterized byconsisting of the following components in percentage by mass of 3.00-25.0 percent of retinol and derivatives thereof, 36.5-91.0 percent of hydroxypropyl-gamma-cyclodextrin, 4.00-32.0 percent of hydroxypropyl methylcellulose stearoyl ether and 2.00-8.0 percent of PEG/PPG/polybutylene glycol-8/5/3 glycerin, wherein the mass ratio of the PEG/PPG/polybutylene glycol-8/5/3 glycerin to the hydroxypropylmethylcellulose stearoyl ether is 1:(2-4). The obtained supramolecular preparation of the retinol and the derivatives thereof has the advantages of good stability, high solubility, low irritation, good anti-wrinkle effect and the like. 本发明涉及一种视黄醇及其衍生物的超分子制剂及其制备方法，其特征在于：由以下质量百分比的组分组成：3.00-25.0%视黄醇及其衍生物，36.5-91.0%羟丙基γ-环糊精，4.00-32.0%羟丙基甲基纤维素硬脂氧基醚，2.00-8.0%PEG/PPG/聚丁二醇-8/5/3甘油，其中PEG/PPG/聚丁二醇-8/5/3甘油和羟丙基甲基纤维素硬脂氧基醚的质量比为1:2-4。本发