UNIVERSAL OR NORMALIZED ANTIBODY FRAMEWORKS FOR IMPROVED FUNCTIONALITY AND MANUFACTURABILITY

The invention provides methods of designing and manufacturing universal or normalized sequence templates for rabbit monoclonal antibodies for diagnostic applications. The invention further provides for methods of optimizing desirable antibody properties, such as thermal stability, long-term stability, expression, deamination/oxidation, and/or aggregation. The invention further provides for universal or normalized rabbit monoclonal antibody templates or frameworks and antibodies derived therefrom. 本发明提供了设计和制造用于兔单克隆抗体的通用或归一化序列模板的方法，所述兔单克隆抗体用于诊断应用。本发明进一步提供了优化期望的抗体特性的方法，所述期望的抗体特性为诸如热稳定性、长期稳定性、表达、脱氨基作用/氧化作用及/或聚集作用。本发明进一步提供了通用或归一化兔单克隆抗体模板或框架以及由其衍生的抗体。