DUAL-FUNCTION ANTIBODIES TARGETING VEGFR2 AND VEGFR3

An isolated antibody, comprising heavy chain complementary determining regions CDR1, CDR2, and CDR3 from a heavy chain variable region sequence having SEQ ID NO: 1 or 3; light chain complementary determining regions CDR1, CDR2, and CDR3 from a light chain variable region sequence having SEQ ID NO: 2...

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Bibliographische Detailangaben
Hauptverfasser:	LIU KEJUN, CHEN LIZONG, CHEN YONGCHANG, XIAO GUANZHONG, HONG WENJUN, SHEN SANTAI, SHI NENGYAO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	An isolated antibody, comprising heavy chain complementary determining regions CDR1, CDR2, and CDR3 from a heavy chain variable region sequence having SEQ ID NO: 1 or 3; light chain complementary determining regions CDR1, CDR2, and CDR3 from a light chain variable region sequence having SEQ ID NO: 2 or 4; the antibody binds specifically to both vascular endothelial growth factor receptor-2 (VEGFR2) and vascular endothelial growth factor receptor-3 (VEGFR3). 本发明关于一种单离抗体，包含重链互补决定区CDR1、CDR2、CDR3与轻链互补决定区CDR1、CDR2、CDR3，其重链互补决定区包含于具有SEQ ID NO:1或3的重链可变区序列，轻链互补决定区包含于具有SEQ ID NO:2或4的轻链可变区序列，该抗体可与血管内皮生长因子受体-2(vascular endothelial growth factor receptor-2,VEGFR2)及VEGFR3特异性结合。