Preparation method of 3-amino-4-chlorobenzoic acid hexadecyl ester

The invention provides a preparation method of 3-amino-4-chlorobenzoic acid hexadecyl ester. The preparation method comprises the following steps: by taking p-chlorobenzoic acid as an initial raw material, firstly carrying out acylating chlorination reaction on p-chlorobenzoic acid, DMF (Dimethyl Formamide) and a chlorination reagent to generate p-chlorobenzoyl chloride; then carrying out esterification reaction with hexadecanol to generate hexadecyl p-chlorobenzoate; then carrying out nitration reaction with sulfuric acid and nitric acid to generate 3-nitro-4-chlorobenzoic acid hexadecyl ester; and finally, carrying out a reduction reaction with hydrogen under the catalysis of raney nickel to generate the 3-amino-4-chlorobenzoic acid hexadecyl ester. The preparation method disclosed by the invention is high in yield, high in product purity and low in cost. 本发明提供了一种3-氨基-4-氯苯甲酸十六酯的制备方法。该制备方法以对氯苯甲酸为起始原料，先与DMF、氯化试剂进行酰氯化反应，生成对氯苯甲酰氯；再与十六醇进行酯化反应，生成对氯苯甲酸十六酯；再与硫酸、硝酸进行硝化反应，生成3-硝基-4-氯苯甲酸十六酯；最后与氢气在雷尼镍的催化下进行还原反应，生成3-氨基-4