Genetically engineered strain for producing ergothioneine and application

The invention provides a genetically engineered strain for high yield of ergothioneine and application. The stain takes escherichia coli as a host, and a coding gene hisG* of a corynebacterium glutamicum ATP phosphoribosyl transferase HisG mutant is integrated on a genome of the host; the copy number of a histidine operon gene hisDBCHAFI is further increased on the genome of the host; a mycobacterium smegmatis ergothioneine operon gene egtBCDE is further integrated on the genome of the host; an Escherichia coli glutamylcysteine ligase encoding gene gshA is integrated on the genome of the host,so that the synthesis of the ergothioneine is promoted; a neurospora crassa C-S lyase coding gene egtE is further integrated on the genome of the host, so that the synthesis of ergothioneine isfurther promoted; and a gene egtB* of a sulfoxide synthase mutant is integrated on a genome of the host, so that synthesis of ergothioneine is further promoted. 本发明提供一株高产麦角硫因的基因工程菌及其应用，该菌株是以大肠杆菌为宿主，在宿主的基因组上整合了谷氨酸棒杆菌ATP转磷酸核糖基酶HisG突变