Formylated bicyclol and preparation method thereof

The invention belongs to the technical field of medicines, and particularly relates to formylated bicyclol and a preparation method thereof. The method comprises the steps that at room temperature, bicyclol is added into a reaction solvent N, N-dimethylformamide, and a first solution is obtained aft...

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Hauptverfasser: ZHAO JIANFEI, XU XIURONG, DAI XINMIN, YUAN BINGZHAN, JIANG XINGKAI, ZHONG FUGUI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of medicines, and particularly relates to formylated bicyclol and a preparation method thereof. The method comprises the steps that at room temperature, bicyclol is added into a reaction solvent N, N-dimethylformamide, and a first solution is obtained after stirring and dissolving; the first solution is cooled to a first temperature, and dropwise addingof phosphorus oxychloride is carried out to obtain a second solution; the second solution reacts at a second temperature, and after the reaction is completed, cooling to room temperature is carried out to obtain a third solution; water and an organic solvent are added into the third solution, and extracting is conducted to obtain an organic layer; after the organic layer is concentrated, obtainedresidues are separated and purified through column chromatography, and formylated bicyclol is obtained. According to the formylated bicyclol and the preparation method thereof provided by the invention, the effects of effecti