Isonicotinic acid derivative II with anti-platelet aggregation, anti-tumor and immunosuppressive activity and application of isonicotinic acid derivative II

The invention provides an isonicotinic acid derivative I with immunosuppressive activity, and the structural general formula of the isonicotinic acid derivative I is shown in the specification, wherein R1 and R2 are connecting sites of side chains, and the side chain is positioned at one of the R1 and R2 sites. The nicotinic acid compound provided by the invention has good immunosuppressive activity, anti-liver tumor activity and anti-type II diabetes activity, strong selectivity and good clinical application value. 本发明提供了一种具有免疫抑制活性的异烟酸衍生物I，其结构通式为：其中R1、R2为侧链的连接位点，侧链位于R1或R2的其中一个位点。本发明提供的烟酸类化合物具有良好的免疫抑制活性及抗肝脏肿瘤活性和抗II型糖尿病的活性，且选择性强，具有良好的临床应用价值。