Dexamethasone sodium phosphate injection and preparation method thereof

The invention belongs to the field of medicines, and particularly relates to a dexamethasone sodium phosphate injection and a preparation method thereof. The dexamethasone sodium phosphate injection comprises the following components in percentage by weight of 1.04%-1.14% of dexamethasone sodium pho...

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Bibliographische Detailangaben
Hauptverfasser: LIU CHUNMEI, WANG ZHICHAO, GUO QIONGYING, LANG FUSHUANG, DAI XINMIN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention belongs to the field of medicines, and particularly relates to a dexamethasone sodium phosphate injection and a preparation method thereof. The dexamethasone sodium phosphate injection comprises the following components in percentage by weight of 1.04%-1.14% of dexamethasone sodium phosphate, 2.56%-2.598% of sodium citrate dehydrate, 0.007%-0.010% of citric acid and the balance of water for injection. According to the dexamethasone sodium phosphate injection and the preparation method thereof provided by the invention, the sodium citrate dehydrate and the citric acid are used asauxiliary materials, so that the safety problem caused by adding an organic solvent and an antioxidant is avoided; the osmotic pressure and the pH value of a preparation are ensured by adopting the proper sodium citrate dehydrate dosage and citric acid dosage; according to the preparation process, the stability of the preparation is ensured by adopting a relatively low liquid preparation temperature and nitrogen filling a