ANTIBODY BINDING SPECIFICALLY TO ECL-2 OF CLAUDIN 3, FRAGMENT THEREOF, AND USE THEREOF

The invention of the present application relates to a use of an antibody binding specifically to ECL-2 of claudin 3 and functional fragments thereof in cancer cell detection, diagnosis, imaging, and application to cancer treatment (anticancer use of the antibody itself, and application to ADC and CA...

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Bibliographische Detailangaben
Hauptverfasser:	PARK HA-YEON, SHIN YOUNG-KEE, KIM YOUNG-DEUK, KIM SONG-SU, YANG HEO-BIN, CHOI JUN-YOUNG, HONG SUNG-YOUL
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention of the present application relates to a use of an antibody binding specifically to ECL-2 of claudin 3 and functional fragments thereof in cancer cell detection, diagnosis, imaging, and application to cancer treatment (anticancer use of the antibody itself, and application to ADC and CAR-expression cells (particularly immune cells)), an antibody that includes a characteristic CDR sequence exerting a remarkable effect in such uses, and a functional fragment thereof. 本申请的发明涉及特异性结合claudin 3的ECL-2的抗体及其功能性片段在癌细胞检测、诊断、成像中的用途以及对于癌症治疗的应用(抗体本身的抗癌用途以及在ADC和CAR表达细胞(特别是免疫细胞)中的应用)，包含在此类用途中发挥显著作用的特征性CDR序列的抗体及其功能性片段。