MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS

Provided are compounds represented by Formula IA: (IA), and the pharmaceutically acceptable salts and solvates thereof, wherein R, R 1a, R 1b, L 1, L 2, L 3, X, A, B and C are as defined as set forthin the specification. Also provided compounds of Formula IA for use to treat a condition or disorder...

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Bibliographische Detailangaben
Hauptverfasser: LI LIUGEN, WANG SHAOMENG, YANG ZHAOYI, TANG GUOZHI, ZHA XIANCHAN, LI DONGBO, CHEN WENMING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:Provided are compounds represented by Formula IA: (IA), and the pharmaceutically acceptable salts and solvates thereof, wherein R, R 1a, R 1b, L 1, L 2, L 3, X, A, B and C are as defined as set forthin the specification. Also provided compounds of Formula IA for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer. 本发明公开内容提供由于式IA表示的化合物:及其可药用盐和溶剂化物,其中R、R1a、R1b、L1、L2、L3、X、和为如说明书中阐述的定义的。本发明还提供式IA的化合物,用于治疗对于Mcl-1抑制有反应的病症或障碍,比如癌症。