VASCULAR REPAIR PATCH

The invention relates to a patch for use in the repair of damaged vasculature, and particularly for the repair of aortic dissection. The vascular repair patch comprises a polymeric substrate having first and second major surfaces, and at least first and second polymer filament layers, wherein the polymer filaments of the first polymer filament layer are oriented in parallel and the polymer filaments of the second polymer filament layer are oriented randomly. The patch may further include thrombogenic agents and/or extracellular matrix compounds to promote vascular tissue regeneration at the repair site. The invention further provides methods of making the patch. 本发明涉及用于修复受损的脉管系统，特别是用于修复主动脉夹层的贴片。血管修复贴片包括具有第一和第二主表面的聚合物基底，以及至少第一和第二聚合物纤丝层，其中第一聚合物纤丝层的聚合物纤丝是平行取向的，第二聚合物纤丝层的聚合物纤丝是随机取向的。该贴片可以进一步包括血栓形成剂和/或细胞外基质化合物，以促进修复部位的血管组织再生。本发明进一步提供了制造贴片的方法。